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10.1126/science.124.3220.484-a Science

CagriSema (closest analog) has Phase 3 data

A New Generation of Drugs: Synthetic Peptides Based on Natural Regulatory Peptides

Comparison across biofluids further highlighted both opportunity and constraint: while lumbar and ventricular CSF showed strong concordance, plasma profiles diverged substantially, particularly for immune-active pathways such as kynurenine metabolism 67 , indicating that treatment-relevant metabolic states are most directly captured in CSF and only partially reflected in peripheral blood